Pfizer Highlights Progress in Accelerating Breakthrough Cancer Medicines at ASCO 2024 Annual Meeting
More than 50 abstracts, including 11 oral presentations, span
New five-year progression-free survival data for LORBRENA® (lorlatinib) in first-line ALK-positive advanced lung cancer
Results from ECHELON-3, third Phase 3 study to demonstrate overall survival benefit for ADCETRIS® (brentuximab vedotin) in a type of lymphoma
“We are excited to participate in our first ASCO Annual Meeting following the creation of Pfizer’s new Oncology organization, where we will highlight our efforts to accelerate breakthrough medicines that help people with cancer live better and longer lives,” said
Key research includes an oral presentation of new five-year progression-free survival (PFS) results from the Phase 3 CROWN study of LORBRENA® (lorlatinib) in previously untreated anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC), which will also be featured in ASCO’s embargoed pre-meeting press briefing on
“At ASCO,
Key ASCO Presentations
Breast Cancer
In breast cancer,
Genitourinary Cancer
Highlights from Pfizer’s genitourinary cancer portfolio will include updated data that continue to reinforce the potential of several recent priority launches, including PADCEV® (enfortumab vedotin-ejfv) in combination with KEYTRUDA® (pembrolizumab) in locally advanced/metastatic urothelial cancer,* XTANDI® (enzalutamide) in non-metastatic castration-sensitive prostate cancer (nmCSPC) with biochemical recurrence at high-risk for metastasis,** and TALZENNA® (talazoparib) in combination with XTANDI in metastatic castration-resistant prostate cancer (mCRPC) with homologous recombination repair (HRR) mutations. Additionally, updated Phase 1 data will be presented for the investigational enhancer of zeste homolog 2 (EZH2) inhibitor mevrometostat in combination with XTANDI in mCRPC;
Hematology-Oncology
In addition to the ECHELON-3 OS results for ADCETRIS in relapsed/refractory DLBCL,
Thoracic Cancer
In its thoracic portfolio, in addition to the LORBRENA CROWN results,
Additional Tumor Types
An oral presentation on extended duration of response from the Phase 3 MOUNTAINEER trial adds to the positive profile of TUKYSA in colorectal cancer. In addition, data will be presented from the innovaTV 301 trial of TIVDAK® (tisotumab vedotin-tftv), for which a supplemental Biologics License Application for the treatment of previously treated recurrent or metastatic cervical cancer was granted priority review by the
Additional information on key
BREAST CANCER |
Oral Presentation (Abstract 3006)
A phase 1 dose expansion study of a first-in-class KAT6 inhibitor — (PF-07248144) in patients with advanced or metastatic ER+ HER2− breast cancer
Mukohara et al |
Poster Presentation (Abstract 3108)
First-in-human phase 1/2a study of the first-in-class, next-generation CDK4-selective inhibitor PF-07220060 + endocrine therapy (ET): Updated safety data in patients with HR+/HER2− mBC
Giordano et al |
Poster Presentation (Abstract 1111)
Overall survival with palbociclib (PAL) plus an aromatase inhibitor (AI) versus AI alone in older patients (pts) with de novo, HR+/HER2− metastatic breast cancer: A SEER-Medicare analysis
Brufsky et al |
Poster Presentation (Abstract 1105)
Tucatinib and trastuzumab for previously treated HER2-mutated metastatic breast cancer (SGNTUC-019): A phase 2 basket study
Okines et al |
GENITOURINARY CANCER |
Oral Presentation (Abstract 4502)
Patient-reported outcomes (PROs) from a randomized, phase 3 trial of enfortumab vedotin plus pembrolizumab (EV+P) versus platinum-based chemotherapy (PBC) in previously untreated locally advanced or metastatic urothelial cancer (la/mUC)
Gupta et al |
Oral Presentation (Abstract 4503)
Impact of exposure on outcomes with enfortumab vedotin in patients with locally advanced or metastatic urothelial cancer
Petrylak et al |
Oral Presentation (Abstract 5005)
EMBARK post-hoc analysis of impact of treatment suspension (TxS) on health-related quality of life (HRQoL)
Freedland et al |
Poster Presentation (Abstract 5021)
Discovery of a novel non-negative matrix factorization (NMF)-based homologous recombination deficiency (HRD) score and subsequent exploration in TALAPRO-2 (TP-2), a phase 3 study of talazoparib (TALA) + enzalutamide (ENZA) vs placebo (PBO) + ENZA as first-line treatment in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)
Fizazi et al |
Poster Presentation (Abstract 5061)
Phase 1 trial of mevrometostat (PF-06821497), a potent and selective inhibitor of enhancer of zeste homolog 2 (EZH2), in castration-resistant prostate cancer (CRPC)
Schweizer et al |
Poster Presentation (Abstract 5063)
Castro et al |
Poster Presentation (Abstract 4562)
Enfortumab vedotin (EV) with pembrolizumab (P) versus chemotherapy (chemo) in previously untreated locally advanced or metastatic urothelial carcinoma (la/mUC): Analysis of cisplatin (cis)-eligible population from EV-302/KEYNOTE-A39
Bedke et al |
Poster Presentation (Abstract 4563)
Enfortumab vedotin (EV) with pembrolizumab (P) versus chemotherapy (chemo) in previously untreated locally advanced or metastatic urothelial carcinoma (la/mUC): Analysis of the cisplatin (cis)-ineligible population from EV-302/KEYNOTE-A39
Van Der Heijden et al |
HEMATOLOGY-ONCOLOGY |
Oral Presentation (Abstract LBA7005)
Brentuximab vedotin in combination with lenalidomide and rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma: Results from the phase 3 ECHELON-3 study
Kim et al |
Poster Presentation (Abstract 7053)
Seven-year overall survival analysis from ECHELON-1 study of A+AVD versus ABVD in patients with previously untreated stage III/IV classical Hodgkin lymphoma
Ansell et al |
Poster Presentation (Abstract 7522)
Evaluation of cytokine release syndrome (CRS) in patients with relapsed or refractory multiple myeloma (RRMM) receiving step-up priming doses and longer dosing intervals of elranatamab: MagnetisMM-9
Sborov D |
THORACIC CANCER |
Oral Presentation (Abstract LBA8503)
Lorlatinib vs crizotinib in treatment-naïve patients with advanced ALK+ non-small cell lung cancer: 5-year progression-free survival and safety from the CROWN study
Solomon et al |
Rapid Oral Presentation (Abstract 8521)
Efficacy and safety of sigvotatug vedotin, an investigational ADC, in NSCLC: Updated phase 1 results (SGNB6A-001)
Peters et al |
GYNECOLOGICAL CANCER |
Poster Presentation (Abstract 5531)
Tisotumab vedotin in 2L/3L recurrent or metastatic cervical cancer: subsequent therapy data from ENGOT-cx12/GOG-3057/innovaTV 301
|
GASTROINTESTINAL CANCER |
Oral Presentation (Abstract 3509)
Final results of a phase 2 study of tucatinib and trastuzumab for HER2-positive mCRC (MOUNTAINEER)
Strickler et al |
*
**XTANDI® is jointly developed and commercialized by
***
****TIVDAK® is co-owned by Genmab and
Prescribing Information for Pfizer Medicines
Please see full Prescribing Information, including BOXED WARNING, for ADCETRIS® (brentuximab vedotin).
Please see full Prescribing Information, including BOXED WARNING, for ELREXFIOTM (elranatamab-bcmm).
Please see full Prescribing Information for IBRANCE® (palbociclib) tablets and IBRANCE® (palbociclib) capsules.
Please see full Prescribing Information for LORBRENA® (lorlatinib).
Please see full Prescribing Information, including BOXED WARNING, for PADCEV® (enfortumab vedotin).
Please see full Prescribing Information for TUKYSA® (tucatinib).
Please see full Prescribing Information for TALZENNA® (talazoparib).
Please see full Prescribing Information, including BOXED WARNING, for TIVDAK® (tisotumab vedotin-tftv).
Please see full Prescribing Information for XTANDI® (enzalutamide).
About Pfizer Oncology
At Pfizer Oncology, we are at the forefront of a new era in cancer care. Our industry-leading portfolio and extensive pipeline includes three core mechanisms of action to attack cancer from multiple angles, including small molecules, antibody-drug conjugates (ADCs), and bispecific antibodies, including other immune-oncology biologics. We are focused on delivering transformative therapies in some of the world’s most common cancers, including breast cancer, genitourinary cancer, hematology-oncology, and thoracic cancers, which includes lung cancer. Driven by science, we are committed to accelerating breakthroughs to help people with cancer live better and longer lives.
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Disclosure Notice
The information contained in this release is as of
This release contains forward-looking information about Pfizer’s oncology portfolio of marketed and investigational therapies; expectations for our product pipeline, in-line products and product candidates, including anticipated regulatory submissions, data read-outs, study starts, approvals, launches, clinical trial results and other developing data; anticipated operating and financial performance; the development or commercial potential of our product pipeline, in-line products, product candidates and additional indications or combinations, including expected clinical trial protocols, the potential and timing for the initiation and progress of clinical trials and data read-outs from trials; the timing and potential for the submission of applications for and receipt of regulatory approvals; the timing and potential for product launches and commercialization; expected breakthrough, best- or first-in-class or blockbuster status or expected market entry of our medicines; potential patients reached; the regulatory landscape; the competitive landscape; and other statements about our business, operations and financial results that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Risk and uncertainties include, among other things, uncertainties regarding the commercial success of Pfizer’s oncology portfolio; the uncertainties inherent in research and development, including the ability to meet anticipated clinical endpoints, commencement and/or completion dates for our clinical trials, regulatory submission dates, regulatory approval dates and/or launch dates, as well as the possibility of unfavorable new clinical data and further analyses of existing clinical data; risks associated with interim and preliminary data; the risk that clinical trial data are subject to differing interpretations and assessments by regulatory authorities; whether regulatory authorities will be satisfied with the design of and results from our clinical studies; whether and when any drug applications, biologics license applications and/or emergency use authorization applications may be filed in any jurisdictions for any potential indication for Pfizer’s product candidates; whether and when any such applications that may be filed for any of Pfizer’s product candidates may be approved by regulatory authorities, which will depend on myriad factors, including making a determination as to whether the product's benefits outweigh its known risks and determination of the product's efficacy and, if approved, whether any such product candidates will be commercially successful; decisions by regulatory authorities impacting labeling, manufacturing processes, safety and/or other matters that could affect the availability or commercial potential of Pfizer’s products or product candidates, including development of products or therapies by other companies; manufacturing capabilities or capacity; uncertainties regarding the ability to obtain recommendations from vaccine technical committees and other public health authorities and uncertainties regarding the commercial impact of any such recommendations; uncertainties regarding the impact of COVID-19 on Pfizer’s business, operations and financial results; and competitive developments.
A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended
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